| Bioactivity | Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research[1]. |
| Invitro | Nrf2/HO-1 activator 1 (0.3-30 µM; 24 h) exhibits potent neuroprotection in both 6-OHDA- and rotenone-induced cell death models[1].Nrf2/HO-1 activator 1 (1-30 µM; 6 h) increases HO-1 expression in PC12 cells[1].Nrf2/HO-1 activator 1 (12 µM; 1-12 h) increases phosphorylation of ERK1/2, JNK, and Akt in PC12 cells[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | Nrf2/HO-1 activator 1 inhibits the production of lipid peroxide in rat brain homogenates by 50.5% at 100 μM[1]. |
| Name | Nrf2/HO-1 activator 1 |
| Formula | C21H18O5 |
| Molar Mass | 350.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qili Lu, et al. Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling. Eur J Med Chem. 2022 Nov 15;242:114692. |