| Bioactivity | Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis[1]. |
| Invitro | Nrf2 activator-9 (compound D-36) (5 μM, 10 μM; 6 h) 逆转了 50 μg/mL oxLDL 诱导 HUVEC 凋亡[1]。Nrf2 activator-9 (5 μM, 10 μM; 6 h, 24 h) 促进 Nrf2 的核易位，激活 Nrf2 的抗氧化通路，形成对 HUVEC 的保护作用[1]。 0 --> Nrf2 activator-9 相关抗体: |
| Name | Nrf2 activator-9 |
| Formula | C26H27N5O4 |
| Molar Mass | 473.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang J, et al. Discovery of marine phidianidine-based Nrf2 activators and their potential against oxLDL- and HG-induced injury in HUVECs. Bioorg Med Chem Lett. 2023 Sep 7;95:129468.. . |