| Bioactivity | Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation[1]. |
| Target | EC50: 37.9 nM (Nrf2). |
| Name | Nrf2 activator-8 |
| Formula | C13H11ClN2O3S |
| Molar Mass | 310.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim B, et al. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects. Eur J Med Chem. 2023 Aug 5;256:115433. |
Nrf2 activator-8
CAS: F: C13H11ClN2O3S W: 310.76
Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and
Data collection：peptidedb@qq.com
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