| Bioactivity | Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2]. |
| Invitro | (±)-Norfenfluramine interacts with 5-hydroxytryptamine (5-HT) transporters to release 5-HT from neurons[1].(±)-Norfenfluramine increases [3H]dopamine and [3H] norepinephrine release in vitro[1]. |
| Name | Norfenfluramine |
| CAS | 1886-26-6 |
| Formula | C10H12F3N |
| Molar Mass | 203.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. [2]. Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. |
Norfenfluramine
CAS: 1886-26-6 F: C10H12F3N W: 203.20
Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can in
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