Noraramtide_product_DataBase

Bioactivity	Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity[1].
CAS	2580150-96-3
Sequence	Ala-Arg-{2-aminoheptanoicacid}-Tyr-His-Asp-Gly-Val-Leu-{Phe(4-phenyl)}-{2-aminoheptanoicacid}-{d-Cys(s-carboxymethyl)}-{XGly}-{γGlu}-{γGlu}-{d-γGlu}-{γGlu}-{γGlu}-Gly-Gly-Asp-Cys-Ala-Trp-His-Leu-Gly-Glu-Leu-Val-Trp-Cys-Thr (Sulfidebridge:Ala1-Cys13,Disulfidebridge:Cys24-Cys34) X= NH2-PEG6-((6S)-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-6-yl)methyl hydrogen carbonate-piperidine-4-carboxylic acid
Shortening	AR-{2-aminoheptanoicacid}-YHDGVL-{Phe(4-phenyl)}-{2-aminoheptanoicacid}-{d-Cys(s-carboxymethyl)}-{XGly}-{γGlu}-{γGlu}-{d-γGlu}-{γGlu}-{γGlu}-GGDCAWHLGELVWCT (Sulfidebridge: Ala1-Cys13,Disulfidebridge:Cys24-Cys34) X= NH2-PEG6-((6S)-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-6-yl)methyl hydrogen carbonate-piperidine-4-carboxylic acid
Formula	C210H300N48O65S3
Molar Mass	4633.11
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Birch G C, et al. Expansion, persistence, and characteristics of autologous, Bhv-1100 armored memory-like NK cells infused prior to autologous stem cell transplant in MRD+ multiple myeloma patients: a first-in-human trial[J]. Blood, 2023, 142: 2105.

PeptideDB

Noraramtide

CAS: 2580150-96-3 F: C210H300N48O65S3 W: 4633.11