Bioactivity | Non-PEGylated/naked ARC1905 is is an anti-C5 RNA aptamer without PEG conjugation. Non-PEGylated/naked ARC1905 inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. Non-PEGylated/naked ARC1905 is being used for the study of age-related macular degeneration (AMD). |
Name | Non-PEGylated/naked ARC1905 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Jaffe GJ, Westby K, Csaky KG, et al. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021;128(4):576-586. [2]. Patel SS, Lally DR, Hsu J, et al. Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial [published online ahead of print, 2023 Mar 24]. Eye (Lond). 2023;10.1038/s41433-023-02497-w. |