PeptideDB

Non-PEGylated/naked ARC1905

CAS: F: W:

Non-PEGylated/naked ARC1905 is is an anti-C5 RNA aptamer without PEG conjugation. Non-PEGylated/naked ARC1905 inhibits t
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Bioactivity Non-PEGylated/naked ARC1905 is is an anti-C5 RNA aptamer without PEG conjugation. Non-PEGylated/naked ARC1905 inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. Non-PEGylated/naked ARC1905 is being used for the study of age-related macular degeneration (AMD).
Name Non-PEGylated/naked ARC1905
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Jaffe GJ, Westby K, Csaky KG, et al. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021;128(4):576-586. [2]. Patel SS, Lally DR, Hsu J, et al. Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial [published online ahead of print, 2023 Mar 24]. Eye (Lond). 2023;10.1038/s41433-023-02497-w.