| Bioactivity | Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor. |
| Target | serotonin-norepinephrine reuptake |
| Invitro | The in vitro effect of Nitroxazepine (Sintamil), as a modulator alone and in combination with hydroxyurea (HU), on cytotoxicity is studied in 16 cases of human chronic myeloid leukemia (CML). The cytotoxicity of the drugs as a function of the exposure dose (HU, 100 μM; Nitroxazepine, 10 μg/mL) and the exposure time (1 h) to the agent is investigated. Cytotoxicity is evaluated as the inhibition of incorporation of [3H-methyl]thymidine in the nucleic acids of CML cells. Cytotoxicity of HU is greatly enhanced (P 0 --> Nitroxazepine hydrochloride 相关抗体: |
| CAS | 16398-39-3 |
| Formula | C18H20ClN3O4 |
| Molar Mass | 377.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pradhan SG, et al. Augmentation of hydroxyurea cytotoxicity by sintamil in human chronic myeloid leukemia cells. Tumori. 1986 Oct 31;72(5):507-10. |
Nitroxazepine hydrochloride
CAS: 16398-39-3 F: C18H20ClN3O4 W: 377.82
Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.