| Bioactivity | Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection[1][2]. |
| Invitro | Nitidanin 对恶性疟原虫的 D6 和 W2 克隆品有抑制作用，IC50 值分别为 21.2 和 18.4 μM[1]。Nitidanin 对人口腔表皮样癌细胞 (KB) 显示出非细胞毒性作用，EC50值 >99 μM[1]。Nitidanin 对人肝癌 Huh7.5.1 细胞具有较低的细胞毒性作用，CC50 值为 464.4 μM[2]。Nitidanin (0-250 μM；5 小时) 表现出抗 HCV 活性，IC50 值为 200 μM[2]。 |
| Name | Nitidanin |
| CAS | 171674-89-8 |
| Formula | C21H24O8 |
| Molar Mass | 404.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50. [2]. Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637. |