Nipradolol_product_DataBase

Bioactivity	Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery[1][2].
Invitro	Nipradolol (1 μM; 10 分钟) 抑制钾诱导的犬肌肉收缩，ID50 值为 0.8 μM[1]。Nipradolol (1 μM; 10 分钟) 降低静息张力，抑制近端区钠诱导的收缩[1]。
In Vivo	Nipradolol (0.125%, 0.25%, 0.5%; 静脉注射; 单剂量) 以浓度依赖的方式抑制兔眼眼压的增加[2]。
Name	Nipradolol
CAS	81486-22-8
Formula	C15H22N2O6
Molar Mass	326.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. 3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyran (K-351) and its denitrated derivative on smooth muscle cells of the dog coronary artery. Br J Pharmacol. 1983 May;79(1):285-95. [2]. Nishio K. Alpha-1-adrenoceptor blocking activity of KT-210 (nipradilol ophthalmic solution) on intraocular pressure in the rabbit eye[J]. Nihon Ganka Kiyo (Folia Ophthalmol Jpn), 1999, 50: 655-660.

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