Nicotinamide riboside (triflate)

CAS: 445489-49-6 F: C12H15F3N2O8S W: 404.32

Nicotinamide riboside (triflate), an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3.

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Bioactivity	Nicotinamide riboside (triflate), an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside (triflate) is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside (triflate) reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
Invitro	Nicotinamide riboside (triflate) (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].Nicotinamide riboside (triflate) increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].Nicotinamide riboside (triflate) boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Nicotinamide riboside (triflate) 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Chronic Nicotinamide riboside (triflate) (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	445489-49-6
Formula	C12H15F3N2O8S
Molar Mass	404.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. [2]. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. [3]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.