| Bioactivity | Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells[1]. |
| Target | 42.30 nM human neutrophil elastase |
| Name | Neutrophil elastase inhibitor 4 |
| Formula | C20H21N3O5 |
| Molar Mass | 383.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Donarska B, et al. Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action. Bioorg Chem. 2023 Sep;138:106608. |
Neutrophil elastase inhibitor 4
CAS: F: C20H21N3O5 W: 383.40
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.