| Bioactivity | Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1]. |
| In Vivo | Neutrophil elastase inhibitor 3 (compound 13, 1 mg/kg of body weight, 静脉给药) 显著减轻了大鼠创伤性失血性休克后肺部髓过氧化物酶 (MPO) 活性和水肿的增加。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1234707-32-4 |
| Formula | C14H7BrClNO2 |
| Molar Mass | 336.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem. 2010 Jul;45(7):3111-5. |
Neutrophil elastase inhibitor 3
CAS: 1234707-32-4 F: C14H7BrClNO2 W: 336.57
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and
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