| Bioactivity | Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2]. |
| Invitro | Neuropeptide AF (NPAF) (50, 100, 150, 300, and 600nM) induces a piecemeal degranulation in bone marrow-derived mucosal mast cells (BMMCs). Neuropeptide AF can be considered as a novel modulator of BMMC activity in the neuro-immune communication in the gastrointestinal tract[1]. |
| Name | Neuropeptide AF (cattle) |
| CAS | 99588-52-0 |
| Shortening | AGEGLSSPFWSLAAPQRF-NH2 |
| Formula | C89H130N24O24 |
| Molar Mass | 1920.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Neuropeptide AF (cattle)
CAS: 99588-52-0 F: C89H130N24O24 W: 1920.13
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligan
Data collection：peptidedb@qq.com
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