Neuromedin U-25 (human)_product_DataBase

Bioactivity	Neuromedin U-25 human is the active form of neuromedin U in human. Neuromedin U-25 human inhibits glucose-stimulated insulin secretion, which leads to early-onset obesity. Neuromedin U-25 serves as vasoconstrictor in human vascular beds[1][2].
Invitro	Neuromedin U-25 human (4 pM-2 nM) 与人左心室和冠状动脉中的受体结合，KD 分别为 0.26 和 0.11 nM[1]。Neuromedin U-25 human (0.1 nM-0.1 μM) 内皮非依赖性地收缩冠状动脉、乳动脉和隐静脉，收缩效力 pD2 分别为 8.6，8.0 和 8.2[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Neuromedin U-25 (human) 相关抗体:
CAS	312306-89-1
Sequence	Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
Shortening	FRVDEEFQSPFASQSRGYFLFRPRN-NH2
Formula	C141H203N41O38
Molar Mass	3080.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mitchell JD, et al., Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. Cardiovasc Res. 2009 Feb 1;81(2):353-61. [2]. Alfa RW, et al., Suppression of insulin production and secretion by a decretin hormone. Cell Metab. 2015 Feb 3;21(2):323-334.

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