Neuraminidase-IN-18_product_DataBase

Bioactivity	Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level[1].
Invitro	Neuraminidase-IN-18 (compound N5) 通过 CCK-8 方法显示对 H5N1 的体外抗病毒活性 EC50 值为 3.70 μM[1]。Neuraminidase-IN-18 中的芳香稠环和 1,3,4-恶二唑环很好地嵌入到活性位点中。Neuraminidase-IN-18 可以与活性位点的三个带正电的关键精氨酸残基 (Arg118、Arg292 和 Arg371) 形成强氢键相互作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Neuraminidase-IN-18 相关抗体:
CAS	2935407-32-0
Formula	C22H18FN3O3S
Molar Mass	423.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lin Lin Shang, et al. Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone. European Journal of Medicinal Chemistry, Available online 12 March 2024, 116305.

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