| Bioactivity | Neuraminidase-IN-16 (Compound 43b) is a potent neuraminidase inhibitor with IC50s of 0.031, 0.15, 0.25, 0.60, 0.63 and 10.08 μM against neuraminidase of H5N1, H5N8, H1N1, H3N2, H5N1–H274Y and H1N1–H274Y, respectively[1]. |
| Invitro | Neuraminidase-IN-16 (Compound 43b; 48 h) 在鸡胚成纤维细胞 (CEFs) 中对 H5N1 和 H5N8 表现出抗流感病毒活性，EC50 分别为 2.10±0.44 μM 和 2.28±0.67 μM[1]。Neuraminidase-IN-16 (48 h) 在 MDCK 细胞中对 H1N1 和 H3N2 表现出抗流感病毒活性，EC50 分别为 0.20±0.01 μM 和 11.3±2.5 μM[1]。 |
| In Vivo | Neuraminidase-IN-16 (Compound 43b; 0.039-10 mM; 100 uL) 在无特定病原体 (SPF) 鸡胚蛋中显示抗流感病毒活性[1]。Neuraminidase-IN-16 不能通过血脑屏障[1]。 Animal Model: |
| Name | Neuraminidase-IN-16 |
| Formula | C26H35FN2O4 |
| Molar Mass | 458.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jia R, et al. Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties. Eur J Med Chem. 2023 Apr 5;252:115275. |