| Bioactivity | Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction[1][2]. | ||||||||||||
| Target | ROCK, NET | ||||||||||||
| In Vivo | Netarsudil hydrochloride (0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes[1].Netarsudil hydrochloride (0.04%) produces statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits[2]. Animal Model: | ||||||||||||
| Name | Netarsudil hydrochloride | ||||||||||||
| CAS | 1253952-02-1 | ||||||||||||
| Formula | C28H29Cl2N3O3 | ||||||||||||
| Molar Mass | 526.45 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-54. [2]. Kiel JW, et al. Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits. J Ocul Pharmacol Ther. 2015 Apr;31(3):146-151. |
Netarsudil hydrochloride
CAS: 1253952-02-1 F: C28H29Cl2N3O3 W: 526.45
Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporte
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