| Bioactivity | Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 µM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects[1][2][3]. | ||||||||||||
| Invitro | Necrostatin-5 (1、5、10、50、100 µM) 以剂量依赖性方式抑制 LDH 释放[3]。Necrostatin-5 (100 µM) 保护 MH-S 细胞免受 S. aureus, Listeria monocytogenes, S. pneumoniae, uropathogenic Escherichia coli (UPEC) 的攻击，并防止肺炎球菌溶血素引起的死亡[3]。 | ||||||||||||
| In Vivo | Necrostatin-5 (2.46 mg/kg；腹腔注射) 对大鼠离体心脏模型显示心脏保护作用[2]。 Animal Model: | ||||||||||||
| Name | Necrostatin-5 | ||||||||||||
| CAS | 337349-54-9 | ||||||||||||
| Formula | C19H17N3O2S2 | ||||||||||||
| Molar Mass | 383.49 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Wang K, et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. [2]. Dmitriev YV, et al. Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion. Bull Exp Biol Med. 2013 Jun;155(2):245-8. [3]. González-Juarbe N, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015 Dec 11;11(12):e1005337. |
Necrostatin-5
CAS: 337349-54-9 F: C19H17N3O2S2 W: 383.49
Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 µM. Necrostatin-5 also is a RIP1 inh
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