| Bioactivity | Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2]. | |||||||||
| Target | Necroptosis, 11β-HSD1 | |||||||||
| Invitro | TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) 抑制 TNF-α 诱导的 FADD 缺陷人 Jurkat T 细胞坏死[1]。 Cell Viability Assay[1] Cell Line: | |||||||||
| Name | Necroptosis-IN-3 | |||||||||
| CAS | 547698-18-0 | |||||||||
| Formula | C12H17NOS | |||||||||
| Molar Mass | 223.33 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1. [2]. Nigel Vicker, et al. Compound. Patent US20100120789A1. |
Necroptosis-IN-3
CAS: 547698-18-0 F: C12H17NOS W: 223.33
Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Co
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