| Bioactivity | Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research[1]. |
| Invitro | Nav1.8-IN-9 (Example 116；1 μM) 显示对 Nav1.1、Nav1.3、Nav1.4、Nav1.5、Nav1.6 和 Nav1.7 的抑制率分别为 1.2％、3.7％、 0 --> Nav1.8-IN-7 相关抗体: |
| In Vivo | Pharmacokinetic Parameters of Nav1.8-IN-7 in male Sprague-Dawley rats[1]. |
| CAS | 2761181-58-0 |
| Formula | C22H18ClF4N3O5 |
| Molar Mass | 515.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Junfeng Ren, et al. A benzylamine or benzyl alcohol derivative and its use. CN114031518A. |
Nav1.8-IN-7
CAS: 2761181-58-0 F: C22H18ClF4N3O5 W: 515.84
Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.
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