| Bioactivity | Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1]. |
| Invitro | Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2]. |
| In Vivo | Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3]. Animal Model: |
| Name | Nattokinase |
| CAS | 133876-92-3 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523. [2]. Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567. [3]. Xu J, et, al. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta Haematol. 2014; 132(2): 247-53. |