| Bioactivity | Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine[1][2]. |
| In Vivo | The monkeys (Treated with Plasmodium knowlesi) are treated i.g. once daily for 3 days with 6 or 10 mg/kg of Naphthoquine phosphate respectively. At 24 h after Naphthoquine phosphate administration, the parasite reduction rate is higher than 90%[2]. |
| Name | Naphthoquine phosphate |
| CAS | 173531-58-3 |
| Formula | C24H34ClN3O9P2 |
| Molar Mass | 605.94 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Wang JY, et al. Naphthoquine phosphate and its combination with artemisinine. Acta Trop. 2004 Feb;89(3):375-81. [2]. Wang JY, et al. Therapeutic efficacy of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Dec 30;26(6):442-4. |
Naphthoquine phosphate
CAS: 173531-58-3 F: C24H34ClN3O9P2 W: 605.94
Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing fun
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