| Bioactivity | Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM)[1]. |
| Invitro | Nampt activator-2 (compound 34) (10 μM, 4 h) 导致 A549 肺上皮细胞中 NMN 和 NAD 显着增加[1]。 |
| In Vivo | Nampt activator-2 (compound 34) (1mg/kg 静脉注射和10mg /kg 口服，一次) 表现出低血浆清除率、良好的暴露和出色的口服生物利用度 (%F = 80)[1]。 Animal Model: |
| Name | Nampt activator-2 |
| CAS | 2237268-90-3 |
| Formula | C17H15ClN4O3S |
| Molar Mass | 390.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pinkerton AB, et al. Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett. 2021 Jun 1;41:128007. |
Nampt activator-2
CAS: 2237268-90-3 F: C17H15ClN4O3S W: 390.84
Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate ac
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