| Bioactivity | Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis of 0.013, 19 and 152 nM for δ, μ and κ receptors, respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2]. |
| In Vivo | The hypothermia caused by SNC-80 (35 mg/kg, im) is blocked by a delta2 antagonist, Naltriben (2.5 mg/kg; sc; Sprague-Dawley rats weighing 100-125 g)[2]. |
| Name | Naltriben mesylate |
| CAS | 122517-78-6 |
| Formula | C27H29NO7S |
| Molar Mass | 511.59 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52(1):153-159. [2]. Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049(1):61-69. |
Naltriben mesylate
CAS: 122517-78-6 F: C27H29NO7S W: 511.59
Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis of 0.013, 19 and 152 nM for δ, μ and κ
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