| Bioactivity | NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1]. |
| Invitro | NaV1.2/1.6 channel blocker-1 (compound 13) (1-100 μM) 在稳定表达大鼠 NaV1.6 和人 NaV1.2 同种型的 HEK 293 细胞中分别阻断 48.5% 和 34.0% 的 NaV1.6 和 NaV1.2 钠电流[1]。 |
| Name | NaV1.2/1.6 channel blocker-1 |
| CAS | 1199944-04-1 |
| Formula | C14H14N2OS |
| Molar Mass | 258.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rivara M, et, al. Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers. Letters in Drug Design & Discovery, 2014, 11, 90-97. |
NaV1.2/1.6 channel blocker-1
CAS: 1199944-04-1 F: C14H14N2OS W: 258.34
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.