| Bioactivity | NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia[1]. |
| In Vivo | NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent[1].Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats[1]. |
| Name | NaPi2b-IN-3 |
| CAS | 2227443-66-3 |
| Formula | C45H51N5O7 |
| Molar Mass | 773.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ushiki Y, et al. Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem. 2022;66:116783. |
NaPi2b-IN-3
CAS: 2227443-66-3 F: C45H51N5O7 W: 773.92
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.