| Bioactivity | NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells[1]. |
| Invitro | NY0116 在稳定表达 hNMUR2 的 HEK293 细胞中对 cAMP 具有有效的剂量依赖性抑制作用（EC50 为 1.69 nM）。NY0116 还刺激细胞中的钙信号传导[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NY0116 相关抗体: |
| In Vivo | NY0116（3-30 mg/kg；SC；；持续 14 天）可降低高脂肪饮食的体重、内脏脂肪组织和胆固醇[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1003000-59-6 |
| Formula | C22H23N3O |
| Molar Mass | 345.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Catherine M Sampson, et al. Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425. |