| Bioactivity | NUDT5/14 antagonist 1 (Compound 9) is a selective, dual antagonist for nucleotide diphosphate kinase NUDT5 and NUDT14, with IC50 of 0.27 and 0.16 μM, respectively. NUDT5/14 antagonist 1 binds to Bruton’s tyrosine kinase (BTK) with an IC50 of 0.377 μM[1]. |
| Target | IC50: 0.27 μM (NUDT5), 0.16 μM (NUDT14) |
| Invitro | NUDT5/14 antagonist 1 (>10 μM，72 h) 在癌细胞 BT-474 中不具备细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NUDT5/14 antagonist 1 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C23H24N6O |
| Molar Mass | 400.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Balıkçı E, et al., Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. J Med Chem. 2024 May 9;67(9):7245-7259. |