| Bioactivity | NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice[1][2]. |
| CAS | 1060469-90-0 |
| Formula | C25H25N5O3 |
| Molar Mass | 443.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu J, et al. Virtual High-Throughput Screening To Identify Novel Activin Antagonists. J Med Chem. 2015 Jul 23;58(14):5637-48. [2]. Mekala S, et al. Antagonizing Activin A/p15INK4b Signaling as Therapeutic Strategy for Liver Disease. Cells. 2024 Apr 8;13(7):649. |
NUCC-555
CAS: 1060469-90-0 F: C25H25N5O3 W: 443.50
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin
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