| Bioactivity | NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer[1]. | |||||||||
| Invitro | NUC-7738 (compound 7a; 0-198 μM; 72 h; CCRF-CEM、HL-60、KG-1、MOLT-4、K562、MV4-11、THP-1、HEL92、NCI-H929、RPMI-8226 , Jurkat, Z138, RL, HS445, HepG2, MCF-7, Bx-PC-3, HT29, MIA PaCa-2 and SW620 细胞) 具有抗癌活性和对白细胞谱系具有细胞毒活性，LC50 值为 ＜30 μM[1]。NUC-7738 (1 μM) 在人肝细胞中具有良好的稳定性，t1/2 值为 48.1 min[1]。NUC-7738 与母体核苷相比，在人血浆中的稳定性更高，血浆浓度在长达 4 小时内没有变化[1]。 | |||||||||
| Name | NUC-7738 | |||||||||
| CAS | 2348493-39-8 | |||||||||
| Formula | C26H29N6O7P | |||||||||
| Molar Mass | 568.52 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65(23):15789-15804. |