| Bioactivity | NU-7163 is an ATP-competitive DNA-PK inhibitor (IC50=0.19 μM; Ki=24 nM). NU-7163 enhances the cytotoxicity of ionizing radiation against the HeLa human tumor cell line in vitro[1]. |
| CAS | 503468-03-9 |
| Formula | C18H17NO3 |
| Molar Mass | 295.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Griffin R J, et al. Selective benzopyranone and pyrimido [2, 1-a] isoquinolin-4-one inhibitors of dna-dependent protein kinase: synthesis, structure− activity studies, and radiosensitization of a human tumor cell line in vitro[J]. Journal of medicinal chemistry, 2005, 48(2): 569-585. |