| Bioactivity | NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1]. |
| Invitro | NT376 (1.26-5035 nM, 3 小时) 在 HT-29 细胞中对 IIa 类 Histone deacetylases (HDAC) (IC50=32 nM) 表现出高选择性和高效性，高于其他 HDAC 类别 (IC50= >4.0 µM)，在功能细胞实验中表现略优于 NT160 (HY-149285)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NT376 相关抗体: |
| CAS | 2820208-97-5 |
| Formula | C21H20F4N4O2 |
| Molar Mass | 436.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu S, et al. Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel[J]. Sci Rep. 2024 Jul 2;14(1):15100. |