| Bioactivity | NSD2-IN-1 (compound 38) is a potent and high selective NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1) inhibitor, with an IC50 of 0.11 μM. NSD2-IN-1 can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. NSD2-IN-1 induces apoptosis and cell cycle arrest[1]. |
| Target | IC50: 0.11 ± 0.01 μM (NSD2) |
| Invitro | NSD2-IN-1 inhibits cell proliferation in MV4:11, RS4:11, KMS11, and MM1S cells, with IC50 values of 2.23, 6.30, 8.43, and 10.95 μM, respectively[1]. |
| Name | NSD2-IN-1 |
| CAS | 2797183-37-8 |
| Formula | C29H31N5 |
| Molar Mass | 449.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li N, et al. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J Med Chem. 2022 Jun 15. |