| Bioactivity | NSD-IN-3 (compound 3) is a potent nuclear receptor binding SET domain (NSD) inhibitor. NSD-IN-3 inhibits NSD2-SET and NSD3-SET with IC50 values of 0.81 μM and 0.84 μM, respectively. NSD-IN-3 inhibits histone H3K36 dimethylation and decreases the expression of NSDs-targeted genes in non-small cell lung cancer cells. NSD-IN-3 induces s-phase cell cycle arrest and apoptosis[1]. |
| CAS | 744260-15-9 |
| Formula | C13H12BrN5O |
| Molar Mass | 334.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lianhua Piao, et al. Discovery of potent small molecule inhibitors of histone lysine methyltransferase NSDs. Eur J Med Chem. 2024 Feb 20:268:116264. |
NSD-IN-3
CAS: 744260-15-9 F: C13H12BrN5O W: 334.17
NSD-IN-3 (compound 3) is a potent nuclear receptor binding SET domain (NSD) inhibitor. NSD-IN-3 inhibits NSD2-SET and NS
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