| Bioactivity | NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2]. | ||||||||||||
| Invitro | NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines[1].NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway[1].NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | NSC697923 | ||||||||||||
| CAS | 343351-67-7 | ||||||||||||
| Formula | C11H9NO5S | ||||||||||||
| Molar Mass | 267.26 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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