| Bioactivity | NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer[1]. | ||||||||||||
| Invitro | NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation[1].NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells[1].NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin[1].NSC348884 (1-5 μM; 24 h) induces cell apoptosis[1].NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | NSC348884 | ||||||||||||
| CAS | 81624-55-7 | ||||||||||||
| Formula | C38H40N10 | ||||||||||||
| Molar Mass | 636.79 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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NSC348884
CAS: 81624-55-7 F: C38H40N10 W: 636.79
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell prolif
Data collection：peptidedb@qq.com
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