| Bioactivity | NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1]. |
| Invitro | NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC50 为 10 μM[1]。Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性[1]。Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer[1]。 |
| Name | NSC15520 |
| CAS | 730960-98-2 |
| Formula | C24H34O6 |
| Molar Mass | 418.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Glanzer JG, et al. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg Med Chem. 2011 Apr 15;19(8):2589-95. |