NSC114792_product_DataBase

Bioactivity	NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5[1].
Invitro	NSC114792 (0, 5, 10, 20 µM; 24, 48, 72 h) 以时间和剂量依赖性方式抑制 BaF3-JAK3V674A 和 BKO84 细胞活力[1]。NSC114792 (0, 5, 10, 20 µM) 以剂量依赖性方式降低 p-JAK3 和 p-STAT5 的蛋白表达[1]。NSC114792 (0, 5, 10, 20 µM; 72 h) 以剂量依赖性方式诱导 L540 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NSC114792 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	17392-79-9
Formula	C26H32N4O2S
Molar Mass	464.62
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kim BH, et al. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol Cancer. 2010 Feb 11;9:36.

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