| Bioactivity | NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras[1]. |
| Target | IC50: 6.9 µM (Rce1) |
| Invitro | NSC1011 (25 µM; 20 h) 会在 HCT-116 细胞中诱导 EGFR-H-Ras、EGFR-N-Ras 和 EGFR-K-Ras 错误定位[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NSC1011 相关抗体: |
| CAS | 5335-97-7 |
| Formula | C23H18N2O3 |
| Molar Mass | 370.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mohammed I, et al. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24(2):160-78. |