| Bioactivity | NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. |
| Invitro | NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines[3].NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation[3]. Cell Viability Assay[2] Cell Line: |
| Name | NSC-87877 disodium |
| CAS | 56932-43-5 |
| Formula | C19H11N3Na2O7S2 |
| Molar Mass | 503.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
NSC-87877 disodium
CAS: 56932-43-5 F: C19H11N3Na2O7S2 W: 503.42
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50
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