NSC 689534

CAS: 907958-80-9 F: C19H18N6S W: 362.45

NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has anti

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Bioactivity	NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has antitumor activity[1].
Invitro	NSC 689534/Cu2+ 复合物 (48 h) 抑制 HL60 和 PC3 细胞的细胞活力，IC50s 分别为 0.2 和 0.4 μM，比单独使用 NSC 689534 更有效，约为 4 倍[1]。NSC 689534/Cu2+ 复合物 (2.5 μM，24 小时) 可诱导 PC3 细胞中的氧化应激并消耗 GSH，而单独使用 NSC 689534 则没有效果[1]。NSC 689534/Cu2+ 复合物 (2.5 μM，24 小时) 可诱导 PC3 细胞中的巨自噬 (通过 LC3 积累到大自噬体中) 和 ER 应激反应 (GRP78 和 CHOP 上调)[1]。 0 --> NSC 689534 相关抗体:
In Vivo	NSC 689534/Cu2+ 复合物 (3 mg/kg，腹腔注射，每天一次或两次，持续 5 天) 可抑制 HL60 异种移植模型中的肿瘤生长，而单独使用 NSC 689534 则没有统计学意义[1]。
Name	NSC 689534
CAS	907958-80-9
Formula	C19H18N6S
Molar Mass	362.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chad N Hancock, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. [2]. Hancock CN, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.

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