| Bioactivity | NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2]. |
| Invitro | NSC 140873 (1 至 100 μM，5-6 天) 降低斑马鱼胚胎中的确定性造血功能[2]。NSC 140873 对高表达 RUNX1 的细胞具有抗增殖活性[2]。 |
| Name | NSC 140873 |
| CAS | 106410-13-3 |
| Formula | C13H12ClN3O2 |
| Molar Mass | 277.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1. [2]. Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7. |
NSC 140873
CAS: 106410-13-3 F: C13H12ClN3O2 W: 277.71
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and le
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