| Bioactivity | NS004 is a potassium (BK) channel activator that increases Iberiotoxin (HY-P0190) or Tetraethylammonium (HY-B1793)-sensitive whole-cell efflux currents. NS004 also significantly increased the activity of individual GH3 cell BK channels and rat brain BK channels reorganized into planar lipid bilayers, causing an increase in channel mean open time, a decrease in intermittent time, and an increase in channel voltage/calcium sensitivity[1]. |
| CAS | 141797-92-4 |
| Formula | C14H8ClF3N2O2 |
| Molar Mass | 328.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Opening of Large-Conductance Calcium-Activated Potassium Channels by the Substituted Benzimidazolone NS004 |