| Bioactivity | NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1]. |
| In Vivo | NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1]. Animal Model: |
| Name | NS-8 |
| CAS | 186033-14-7 |
| Formula | C12H10FN3 |
| Molar Mass | 215.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. M Tanaka, et al. A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int. 2003 Dec;92(9):1031-6. |