NR2F1 agonist 1_product_DataBase

Bioactivity	NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model[1].
Invitro	NR2F1 agonist 1（化合物 C26）（0.5 μM，1 μM；18 小时）显着诱导 D-HEp3 细胞中的荧光素酶表达[1]。NR2F1 agonist 1（0.5 μM；7 天）显着下调磷酸肌醇 3-激酶 (PI3K) 信号通路[1]。NR2F1 agonist 1（0.5 μM；7 天）显着上调 SOX9、RARβ 和 p27 的 mRNA 水平[1]。NR2F1 agonist 1（0.5 μM；48 小时）在 D-HEp3 细胞中诱导细胞周期停滞在 G0/G1 期[1]。
In Vivo	NR2F1 agonist 1（0.5 mg/kg/天；腹腔注射；3 周）抑制小鼠模型肺部的原发性肿瘤生长和转移性生长[1]。 Animal Model:
Name	NR2F1 agonist 1
CAS	374101-64-1
Formula	C28H30N4OS
Molar Mass	470.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Khalil BD, et al. An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy. J Exp Med. 2022 Jan 3;219(1):e20210836.

PeptideDB