| Bioactivity | NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1]. |
| Target | EC50: 1 nM (Famesoid X Receptor) |
| Invitro | NR1H4 activator 1 exhibits a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. This assay is aim to determinate the ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR[1]. |
| Name | NR1H4 activator 1 |
| CAS | 2242855-68-9 |
| Formula | C34H53NO7S |
| Molar Mass | 619.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guoqiang Wang, et al. Bile acid derivatives as fxr agonists and methods of use thereof. Patent WO2018152171A1. |
NR1H4 activator 1
CAS: 2242855-68-9 F: C34H53NO7S W: 619.85
NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1
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