| Bioactivity | NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly[1][2]. |
| Invitro | NR160 (化合物 6I) (2.5 μM 和 5 μM; 24 小时) 诱导 α-微管蛋白乙酰化 (ac-α-微管蛋白)[1]。NR160 (1-50 μM; 24 小时) 对 IC50s >20 μM 的白血病细胞系具有较低的细胞毒性[1]。NR160 (2.5 μM, 5 μM; 24 小时) 增强硼替佐米、表柔比星和柔比星对 HL60 细胞的细胞毒性诱导[1]。 Cell Viability Assay[1] Cell Line: |
| Name | NR160 |
| CAS | 2484895-50-1 |
| Formula | C25H21F3N6O3 |
| Molar Mass | 510.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Reßing N, et al. Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 2020 Sep 24;63(18):10339-10351. [2]. Najib N N, et al. Correlation between the acoustic and dynamic mechanical properties of natural rubber foam: Effect of foaming temperature[J]. Materials & Design, 2011, 32(2): 505-511. |