| Bioactivity | NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths[1]. |
| Invitro | NPD8790 表现出显著的物种选择性，抑制秀丽隐杆线虫复合物 I (IC50 = 2.4 µM) 的效果比抑制牛 (IC50 = 27.2 µM)、鼠心脏线粒体 (IC50 = 28.8 µM) 或人类线粒体 (IC50 >75 μM) 的复合物 I 的效果更强[1]。NPD8790 对所有线虫物种的复合物 I 的效果相似 (C. briggsae，IC50 = 1.6 μM；P. pacificus，IC50 = 2.1 μM；P. hermaphrodita，IC50 = 1.1 μM)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NPD8790 相关抗体: |
| CAS | 615281-26-0 |
| Formula | C20H24N2 |
| Molar Mass | 292.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Taylor Davie, et al. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024 May 8;15(1):3367. |