| Bioactivity | NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1]. | ||||||||||||
| Target | pKi: 6.9 (TbrPDEB1); pIC50: 6.2 (T. brucei) (NPD-1335) | ||||||||||||
| Name | NPD-1335 | ||||||||||||
| CAS | 2376326-31-5 | ||||||||||||
| Formula | C28H29N3O3 | ||||||||||||
| Molar Mass | 455.55 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. de Heuvel E, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896(19)30790-4. |
NPD-1335
CAS: 2376326-31-5 F: C28H29N3O3 W: 455.55
NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. bruce
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