| Bioactivity | NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, is a tandem pore domain weak inward rectifying K+ channel (TWIK2) channel blocker. NPBA suppresses NLRP3 inflammasome activation in macrophages[1]. | ||||||||||||
| Name | NPBA | ||||||||||||
| CAS | 524033-40-7 | ||||||||||||
| Formula | C16H14F3N3O3 | ||||||||||||
| Molar Mass | 353.30 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Fuyun Tian, et al. A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues. Mol Pharmacol. 2019 Jul;96(1):26-35. [2]. Yuanxing Zhi, et al. A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 Dec:218:115894. |